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1

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists

Michael Berlin, Pauline C. Ting, Wayne D. Vaccaro, Robert Aslanian, Kevin D. McCormick, Joe F. Lee, Margaret M. Albanese, Mwangi W. Mutahi, John J. Piwinski, Neng-Yang Shih, Luli Duguma, Daniel M. Sol

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 267 KB

english, 2006

2

Relationships between the N-glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures

Chun-Ting Yuen, Patrick L Storring, Richard J. Tiplady, Mabel Izquierdo, Robin Wait, Christopher K. Gee, Peter Gerson, Pauline Lloyd, Jos A. Cremata

Journal:

British Journal of Haematology

Année:

2003

Langue:

english

Fichier:

PDF, 739 KB

english, 2003

3

Effect of multipurpose solutions on in vivo surface wettability of a silicone hydrogel lens

Lau, Jason Ki-kit, So, Hoi-Ting, Chiang, Tsz-Kit, Cho, Pauline

Journal:

Contact Lens and Anterior Eye

Année:

2016

Langue:

english

Fichier:

PDF, 711 KB

english, 2016

4

Calcium signals are necessary to establish auxin transporter polarity in a plant stem cell niche

Li, Ting, Yan, An, Bhatia, Neha, Altinok, Alphan, Afik, Eldad, Durand-Smet, Pauline, Tarr, Paul T., Schroeder, Julian I., Heisler, Marcus G., Meyerowitz, Elliot M.

Journal:

Nature Communications

Année:

2019

Langue:

english

Fichier:

PDF, 13.14 MB

english, 2019

5

Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study

Chen, Jen-Ting, Roberts, Russel, Fazzari, Melissa J., Kashani, Kianoush, Qadir, Nida, Cairns, Charles B., Mathews, Kusum, Park, Pauline, Khan, Akram, Gilmore, James F., Brown, Anne Rain T., Tsuei, Bet

Journal:

Critical Care Medicine

Année:

2020

Fichier:

PDF, 521 KB

2020

6

ChemInform Abstract: A Convenient Preparation of (E)-3-Penten-2-one.

Pauline Chiu, Sun Ting Wong

Journal:

Année:

1999

Fichier:

PDF, 25 KB

1999

7

ChemInform Abstract: Synthesis and NK1/NK2 Receptor Activity of Substituted-4(Z)-(methoxyimino)pentyl-1-piperazines.

Pauline C. Ting, Joe F. Lee, John C. Anthes, Neng-Yang Shih, John J. Piwinski

Journal:

Année:

2001

Fichier:

PDF, 35 KB

2001

8

ChemInform Abstract: Synthesis of Substituted 4-(Z)-(Methoxyimino)pentyl-1-piperidines as Dual NK1/NK2 Inhibitors.

Pauline C. Ting, Joe F. Lee, John C. Anthes, Neng-Yang Shih, John J. Piwinski

Journal:

Année:

2001

Fichier:

PDF, 31 KB

2001

9

ChemInform Abstract: Identification of a Novel 1′-[5-((3,5-Dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4- (methoxyimino)pentyl]-2-oxo-(1,4′-bipiperidine) (I) as a Dual NK1/NK2 Antagonist.

Pauline C. Ting, Joe F. Lee, Neng-Yang Shih, John J. Piwinski, John C. Anthes, Richard W. Chapman, Charles A. Rizzo, John A. Hey, Kwokei Ng, Amin A. Nomeir

Journal:

Année:

2002

Fichier:

PDF, 31 KB

2002

10

The Synthesis of Substituted Fluorenes as Novel Non-imidazole Histamine H3 Inhibitors.

Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Wing C. Tom, Daniel M. Solomon, Robert Aslanian, Neng-Yang Shih, Robert West

Journal:

Année:

2003

Fichier:

PDF, 142 KB

2003

11

The Synthesis of Substituted Bipiperidine Amide Compounds as CCR3 Antagonists.

Pauline C. Ting, et al. et al.

Journal:

Année:

2005

Fichier:

PDF, 28 KB

2005

12

ChemInform Abstract: Palladium-Catalyzed Negishi α-Arylation of Alkylsulfones.

Gang Zhou, Pauline C. Ting, Robert G. Aslanian

Journal:

Année:

2010

Fichier:

PDF, 47 KB

2010

13

DNA replication in homogenates of Physarum polycephalum

E. N. Brewer, Pauline Ting

Journal:

Journal of Cellular Physiology

Année:

1975

Langue:

english

Fichier:

PDF, 667 KB

english, 1975

14

Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors

Rongze Kuang, Ho-Jane Shue, David J. Blythin, Neng-Yang Shih, Danlin Gu, Xiao Chen, John Schwerdt, Ling Lin, Pauline C. Ting, Xiaohong Zhu, Robert Aslanian, John J. Piwinski, Li Xiao, Daniel Prelusky,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 237 KB

english, 2007

15

Synthesis of dibenzo[a,d]cycloheptanes as cytokine biosynthesis inhibitors

Pauline C. Ting, Joe F. Lee, Daniel M. Solomon, Sidney R. Smith, Carol A. Terminelli, James P. Jakway, Demetris N. Zambas

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1995

Langue:

english

Fichier:

PDF, 218 KB

english, 1995

16

The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists

Pauline C. Ting, Joe F. Lee, Jie Wu, Shelby P. Umland, Robert Aslanian, Jianhua Cao, Youhao Dong, Charles G. Garlisi, Eric J. Gilbert, Ying Huang, James Jakway, Joseph Kelly, Zhidan Liu, Stuart McComb

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 124 KB

english, 2005

17

The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists

Pauline C. Ting, Shelby P. Umland, Robert Aslanian, Jianhua Cao, Charles G. Garlisi, Ying Huang, James Jakway, Zhidan Liu, Himanshu Shah, Fang Tian, Yuntao Wan, Neng-Yang Shih

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 191 KB

english, 2005

18

Erratum to “Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists” [Bioorg. Med. Chem. Lett. 16 (2006) 989–994]

Michael Berlin, Pauline C. Ting, Wayne D. Vaccaro, Robert Aslanian, Kevin D. McCormick, Joe F. Lee, Margaret M. Albanese, Mwangi W. Mutahi, John J. Piwinski, Neng-Yang Shih, Luli Duguma, Daniel M. Sol

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 55 KB

english, 2006

19

The synthesis and structure–activity relationship of 4-benzimidazolyl-piperidinylcarbonyl-piperidine analogs as histamine H3 antagonists

Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Jie Wu, Robert Aslanian, Leonard Favreau, Cymbelene Nardo, Walter A. Korfmacher, Robert E. West, Shirley M. Williams, John C. Anthes, Maria A. Rivell

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 2.46 MB

english, 2010

20

The synthesis and structure–activity relationship of pyridazinones as glucan synthase inhibitors

Pauline C. Ting, Rongze Kuang, Heping Wu, Robert G. Aslanian, Jianhua Cao, David W. Kim, Joe F. Lee, John Schwerdt, Gang Zhou, Samuel Wainhaus, Todd A. Black, Anthony Cacciapuoti, Paul M. McNicholas,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.10 MB

english, 2011

21

SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

Gang Zhou, Pauline C. Ting, Robert Aslanian, Jianhua Cao, David W. Kim, Rongze Kuang, Joe F. Lee, John Schwerdt, Heping Wu, R. Jason Herr, Andrew J. Zych, Jinhai Yang, Sang Lam, Samuel Wainhaus, Todd

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2011

22

Palladium-catalyzed Negishi α-arylation of alkylsulfones

Gang Zhou, Pauline C. Ting, Robert G. Aslanian

Journal:

Tetrahedron Letters

Année:

2010

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2010

23

Synthesis and NK1/NK2 receptor activity of substituted-4(Z)-(methoxyimino)pentyl-1-piperazines

Pauline C Ting, Joe F Lee, John C Anthes, Neng-Yang Shih, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 138 KB

english, 2000

24

Synthesis of substituted 4(Z)-(methoxyimino)pentyl-1-piperidines as dual NK1/NK2 inhibitors

Pauline C Ting, Joe F Lee, John C Anthes, Neng-Yang Shih, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 154 KB

english, 2001

25

Structure–Activity relationships of oxime neurokinin antagonists: oxime modifications

Gregory A Reichard, James Spitler, Robert Aslanian, Mwangi wa Mutahi, Neng-Yang Shih, Ling Lin, Pauline C Ting, John C Anthes, John J Piwinski

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 117 KB

english, 2002

26

Identification of a novel, orally bioavailable histamine H3 receptor antagonist based on the 4-benzyl-(1H-imidazol-4-yl) template

Robert Aslanian, Mwangi W. Mutahi, Neng-Yang Shih, Kevin D. McCormick, John J. Piwinski, Pauline C. Ting, Margaret M. Albanese, Michael Y. Berlin, Xiaohong Zhu, Shing-Chun Wong, Stuart B. Rosenblum, Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 150 KB

english, 2002

27

Identification of a novel 1′-[5-((3,5-Dichlorobenzoyl)methylamino)-3-(3,4-dichlorophenyl)-4-(methoxyimino)pentyl]-2-oxo-(1,4′-bipiperidine) as a Dual NK1/NK2 antagonist

Pauline C Ting, Joe F Lee, Neng-Yang Shih, John J Piwinski, John C Anthes, Richard W Chapman, Charles A Rizzo, John A Hey, Kwokei Ng, Amin A Nomeir

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 110 KB

english, 2002

28

Synthesis of a series of sulfinic acid analogs of GABA and evaluation of their GABAB receptor affinities

Nicholas I. Carruthers, James M. Spitler, Shing-Chun Wong, David J. Blythin, Xiao Chen, Ho-Jane Shue, Hoyan S. She, Joe F. Lee, Charles Rizzo, Pauline C. Ting, Robert E. West Jr.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1998

Langue:

english

Fichier:

PDF, 253 KB

english, 1998

29

Differentiation between isomeric triantennary N-linked glycans by negative ion tandem mass spectrometry and confirmation of glycans containing galactose attached to the bisecting (β1-4-GlcNAc) residue in N-glycans from IgG

David J. Harvey, Max Crispin, Chris Scanlan, Bernhard B. Singer, Lothar Lucka, Veronica T. Chang, Catherine M. Radcliffe, Smita Thobhani, Chun-Ting Yuen, Pauline M. Rudd

Journal:

Rapid Communications in Mass Spectrometry

Année:

2008

Langue:

english

Fichier:

PDF, 143 KB

english, 2008

30

Glycyl-d-threonine dihydrate

Pauline Ho, Ting Fong Lai, Richard E. Marsh

Journal:

Journal of Chemical Crystallography

Année:

1979

Langue:

english

Fichier:

PDF, 405 KB

english, 1979

31

Inferior tendon graft to bone tunnel healing at the tibia compared to that at the femur after anterior cruciate ligament reconstruction

Pauline Po Yee Lui, Grace Ho, Wai Ting Shum, Yuk Wa Lee, Po Yan Ho, Wing Nin Lo, Chun Kwong Lo

Journal:

Journal of Orthopaedic Science

Année:

2010

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2010

32

The Synthesis of Substituted Fluorenes as Novel Non-Imidazole Histamine H3 Inhibitors

Pauline C. Ting, Joe F. Lee, Margaret M. Albanese, Wing C. Tom, Daniel M. Solomon, Robert Aslanian, Neng-Yang Shih, Robert West

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 129 KB

english, 2002

33

Brain Metabolic Correlates of Hypoxic-Ischemic Cerebral Necrosis in Mid-Gestational Sheep Fetuses: Significance of Hypotension

Ting, Pauline, Westfall, Margaret V., Yamaguchi, Shun-ichi, Bacher, John D., Myers, Ronald E., Wagner, Kenneth R.

Journal:

Journal of Cerebral Blood Flow and Metabolism

Année:

1986

Langue:

english

Fichier:

PDF, 433 KB

english, 1986

34

Synthesis of spiro[4′,5′,10,11-tetrahydro-5H-dibenzo[a,d]cyclohepten-5-yl-2′(3′H)-furans] as potential cytokine inhibitors

Pauline C. Ting, Daniel M. Solomon

Journal:

Journal of Heterocyclic Chemistry

Année:

1995

Fichier:

PDF, 482 KB

1995

35

Discovery of oxazole-based PDE4 inhibitors with picomolar potency

Rongze Kuang, Ho-Jane Shue, Li Xiao, David J. Blythin, Neng-Yang Shih, Xiao Chen, Danlin Gu, John Schwerdt, Ling Lin, Pauline C. Ting, Jianhua Cao, Robert Aslanian, John J. Piwinski, Daniel Prelusky,

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2012

36

Effect of inhaled roflumilast on the prevention and resolution of allergen-induced late phase airflow obstruction in Brown Norway rats

Richard W. Chapman, Aileen House, Howard Jones, Jennifer Richard, Chander Celly, Dan Prelusky, Pauline Ting, John C. Hunter, James Lamca, Jonathan E. Phillips

Journal:

European Journal of Pharmacology

Année:

2007

Langue:

english

Fichier:

PDF, 784 KB

english, 2007

37

Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration

Richard W. Chapman, Aileen House, Jennifer Richard, Dan Prelusky, James Lamca, Peng Wang, Dan Lundell, Ping Wu, Pauline C. Ting, Joe F. Lee, Robert Aslanian, Jonathan E. Phillips

Journal:

European Journal of Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 671 KB

english, 2010

38

Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPγS binding

Yuntao Wan, James P Jakway, Hongchen Qiu, Himanshu Shah, Charles G Garlisi, Fang Tian, Pauline Ting, David Hesk, R.W Egan, M.Motasim Billah, Shelby P Umland

Journal:

European Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 205 KB

english, 2002

39

Stereocontrolled synthesis of trans-2,5-disubstituted tetrahydrofurans

Ting, Pauline C., Bartlett, Paul A.

Journal:

Journal of the American Chemical Society

Année:

1984

Langue:

english

Fichier:

PDF, 531 KB

english, 1984

40

Inhibition of fucosyltransferase VII by gallic acid and its derivatives

Xiaoda Niu, Xuedong Fan, Jing Sun, Pauline Ting, Satwant Narula, Daniel Lundell

Journal:

Archives of Biochemistry and Biophysics

Année:

2004

Langue:

english

Fichier:

PDF, 288 KB

english, 2004

41

Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors

Andrew J. Zych, Sang Q. Lam, David M. Jenkins, R. Jason Herr, Pauline C. Ting, Joe F. Lee, Rongze Kuang, Heping Wu, David W. Kim, Robert G. Aslanian, Samuel Wainhaus, Todd A. Black, Anthony Cacciapuot

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 1.81 MB

english, 2012

42

The optimization of pyridazinone series of glucan synthase inhibitors

Rongze Kuang, Heping Wu, Pauline C. Ting, Robert G. Aslanian, Jianhua Cao, David W. Kim, Joe F. Lee, John Schwerdt, Gang Zhou, R. Jason Herr, Andrew J. Zych, Jinhai Yang, Sang Q. Lam, David M. Jenkins

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2012

Langue:

english

Fichier:

PDF, 3.40 MB

english, 2012

43

Substituted 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-ones as potential antiinflammatory agents

Ting, Pauline C., Kaminski, James J., Sherlock, Margaret H., Tom, Wing C., Lee, Joe F., Bryant, Robert W., Watnick, Arthur S., McPhail, Andrew T.

Journal:

Journal of Medicinal Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 1.18 MB

english, 1990

44

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W., Ting, Pauline C., Kuethe, Jeffrey T., Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Spe

Journal:

ACS Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 373 KB

english, 2013

45

Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors

Ting, Pauline C., Lee, Joe F., Zorn, Nicolas, Kim, Hyunjin M., Aslanian, Robert G., Lin, Mingxiang, Smith, Michelle, Walker, Scott S., Cook, John, Van Heek, Margaret, Lachowicz, Jean

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 3.25 MB

english, 2013

46

Radical cyclization of oxime ethers

Bartlett, Paul A., McLaren, Kevin L., Ting, Pauline C.

Journal:

Journal of the American Chemical Society

Année:

1988

Langue:

english

Fichier:

PDF, 283 KB

english, 1988

47

A Useful Pd-Catalyzed Negishi Coupling Approach to Benzylic Sulfonamide Derivatives

Zhou, Gang, Ting, Pauline, Aslanian, Robert, Piwinski, John J.

Journal:

Organic Letters

Année:

2008

Langue:

english

Fichier:

PDF, 133 KB

english, 2008

48

Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors

Zhou, Gang, Ting, Pauline C., Wishart, Grant, Zorn, Nicolas, Aslanian, Robert G., Lin, Mingxiang, Smith, Michelle, Walker, Scott S., Cook, John, Van Heek, Margaret, Lachowicz, Jean

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 2.43 MB

english, 2014

49

Discovery of oral and inhaled PDE4 inhibitors

Ting, Pauline C., Lee, Joe F., Kuang, Rongze, Cao, Jianhua, Gu, Danlin, Huang, Ying, Liu, Zhidan, Aslanian, Robert G., Feng, Kung-I., Prelusky, Daniel, Lamca, James, House, Aileen, Phillips, Jonathan

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 2.51 MB

english, 2013

50

Paper 126: Evaluation of BMD/Bone Microarchitectural Changes Along Bone Tunnel and Surrounding Host Bone After Anterior Cruciate Ligament Reconstruction Using Micro-CT

Lui, Pauline Po Yee, Fu, Sai Chuen, Chan, Kai-Ming, Ho, Grace, Shum, Wai Ting, Lee, Suk Wa, Yung, Patrik S.H., Lee, Suk Wah, Ho, Po Yan, Lo, Wing Nin, Mok, Tsui Yu

Journal:

Arthroscopy: The Journal of Arthroscopic & Related Surgery

Année:

2012

Langue:

english

Fichier:

PDF, 51 KB

english, 2012